Jaw-Wen Chen Selected Research

Ginkgo biloba extract (Rokan)

2/2021	Nrf-2 mediated heme oxygenase-1 activation contributes to the anti-inflammatory and renal protective effects of Ginkgo biloba extract in diabetic nephropathy.
5/2012	Ginkgo biloba extract reduces high-glucose-induced endothelial adhesion by inhibiting the redox-dependent interleukin-6 pathways.
2/2011	Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract.
12/2006	Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules.
9/2003	Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells.
1/2002	Effects of Ginkgo biloba extract on the proliferation of vascular smooth muscle cells in vitro and on intimal thickening and interleukin-1beta expression after balloon injury in cholesterol-fed rabbits in vivo.

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Jaw-Wen Chen Research Topics

Disease

41	Atherosclerosis 06/2022 - 01/2002
30	Cardiovascular Diseases (Cardiovascular Disease) 12/2020 - 08/2003
29	Heart Failure 01/2022 - 08/2003
28	Coronary Artery Disease (Coronary Atherosclerosis) 10/2021 - 07/2002
27	Hypertension (High Blood Pressure) 01/2022 - 04/2004
26	Inflammation (Inflammations) 07/2022 - 05/2003
24	Myocardial Infarction 01/2022 - 01/2007
21	Ischemic Stroke 12/2021 - 01/2007
16	Ischemia 01/2020 - 08/2009
14	Diabetes Mellitus 01/2021 - 04/2010
11	Chronic Renal Insufficiency 01/2020 - 05/2011
10	Type 2 Diabetes Mellitus (MODY) 01/2021 - 11/2009
10	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 07/2004
7	Hyperplasia 06/2022 - 01/2002
7	Stroke (Strokes) 01/2022 - 03/2013
6	Diabetic Nephropathies (Diabetic Nephropathy) 07/2022 - 08/2014
6	Insulin Resistance 01/2021 - 01/2013
6	Coronary Disease (Coronary Heart Disease) 01/2021 - 03/2010
6	Hyperglycemia 01/2021 - 01/2005
6	Hypercholesterolemia 03/2020 - 12/2004
5	Atrial Fibrillation 12/2020 - 04/2012
5	Neoplasms (Cancer) 03/2014 - 04/2011
5	Disease Progression 01/2012 - 03/2006
5	Essential Hypertension 10/2011 - 11/2009
4	Hypertrophy 07/2022 - 08/2014
4	Pathologic Constriction (Stenosis) 01/2022 - 04/2004
4	Acute Coronary Syndrome 07/2021 - 01/2013
4	Chronic Kidney Failure (Chronic Renal Failure) 01/2021 - 03/2013
4	Thrombosis (Thrombus) 04/2016 - 10/2005
3	Fibrosis (Cirrhosis) 07/2022 - 03/2013
3	Vascular System Injuries 06/2022 - 12/2007
3	Heart Arrest (Cardiac Arrest) 01/2022 - 03/2017
3	Acute Kidney Injury (Acute Renal Failure) 01/2021 - 07/2013
3	Cardiomyopathies (Cardiomyopathy) 01/2021 - 05/2017
3	Abdominal Aortic Aneurysm 01/2021 - 12/2013
3	Atherosclerotic Plaque (Atheroma) 09/2020 - 01/2002
3	Death (Near-Death Experience) 05/2020 - 03/2011
3	Obesity 01/2020 - 03/2014
3	Chronic Obstructive Pulmonary Disease (COPD) 01/2020 - 10/2011
3	Stable Angina 12/2019 - 10/2004
3	Arteriovenous Fistula 10/2019 - 01/2009
3	Albuminuria 11/2018 - 07/2011
3	Hyperuricemia 02/2018 - 01/2012
3	Cardiomegaly (Heart Hypertrophy) 05/2017 - 01/2016
3	Peripheral Arterial Disease 04/2017 - 03/2016

Drug/Important Bio-Agent (IBA)

22	LipidsIBA 12/2021 - 06/2002
19	erucylphosphocholineIBA 01/2021 - 06/2007
18	omega-Chloroacetophenone (Mace)IBA 01/2022 - 12/2008
16	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2021 - 09/2005
16	C-Reactive ProteinIBA 01/2020 - 05/2004
13	Glucose (Dextrose)FDA LinkGeneric 07/2022 - 07/2004
13	Biomarkers (Surrogate Marker)IBA 12/2021 - 10/2004
11	oxidized low density lipoproteinIBA 07/2021 - 12/2005
11	AdiponectinIBA 01/2020 - 12/2009
11	AntioxidantsIBA 07/2016 - 01/2002
9	CholesterolIBA 01/2020 - 01/2002
8	CytokinesIBA 06/2022 - 09/2003
8	Proteins (Proteins, Gene)FDA Link 09/2020 - 06/2009
8	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 12/2007
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 01/2002
7	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 08/2009
7	Triglycerides (Triacylglycerol)IBA 04/2017 - 07/2004
6	Heme Oxygenase-1IBA 07/2022 - 07/2002
6	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2021 - 09/2005
6	Ginkgo biloba extract (Rokan)IBA 02/2021 - 01/2002
6	Streptozocin (Streptozotocin)FDA Link 01/2021 - 08/2012
6	BilirubinIBA 01/2019 - 08/2008
5	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2022 - 09/2003
5	NADPH Oxidases (NAD(P)H oxidase)IBA 07/2022 - 12/2006
5	Angiotensin Receptor AntagonistsIBA 12/2021 - 12/2006
5	Fenofibrate (CiL)FDA LinkGeneric 01/2021 - 05/2013
5	LigandsIBA 01/2021 - 12/2006
5	Insulin (Novolin)FDA Link 01/2020 - 01/2005
4	AlbuminsIBA 07/2022 - 08/2010
4	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)IBA 01/2022 - 08/2014
4	Fatty Acid-Binding ProteinsIBA 12/2020 - 01/2018
4	NF-kappa B (NF-kB)IBA 09/2020 - 01/2002
4	LDL CholesterolIBA 08/2020 - 01/2013
4	pro-brain natriuretic peptide (1-76)IBA 01/2020 - 08/2007
4	Pharmaceutical PreparationsIBA 02/2018 - 04/2004
4	ThiazidesIBA 01/2016 - 12/2009
4	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 12/2013 - 11/2004
4	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2013 - 11/2002
3	Uric Acid (Urate)IBA 07/2022 - 02/2018
3	Hydralazine (Apresoline)FDA LinkGeneric 07/2022 - 01/2015
3	trimethyloxamine (trimethylamine N-oxide)IBA 06/2022 - 12/2019
3	CalciumIBA 01/2022 - 08/2005
3	CC ChemokinesIBA 01/2021 - 01/2016
3	Interleukin-6 (Interleukin 6)IBA 01/2021 - 05/2012
3	HDL CholesterolIBA 12/2020 - 01/2012
3	Matrix Metalloproteinase 2 (Gelatinase A)IBA 09/2020 - 12/2007
3	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2020 - 08/2007
3	Blood Glucose (Blood Sugar)IBA 01/2020 - 01/2005
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2017 - 05/2013
3	IndicanIBA 04/2016 - 07/2013

Therapy/Procedure

14	Percutaneous Coronary Intervention 10/2021 - 01/2007
14	Therapeutics 04/2017 - 04/2004
8	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/2017 - 01/2007
6	Renal Dialysis (Hemodialysis) 01/2020 - 01/2009
4	Heart Transplantation (Grafting, Heart) 01/2012 - 08/2003